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The Real-time Sign Language Recognition System Is Developed For Recognising The Gestures Of Indian Sign Language (ISL). Generally, Sign Languages Consist Of Hand Gestures And Facial Expressions. For Recognising The Signs, The Regions Of Interest (ROI) Are Identified And Tracked Using The Skin Segmentation Feature Of OpenCV. The Training And Prediction Of Hand Gestures Are Performed By Applying Fuzzy C-means Clustering Machine Learning Algorithm. The Gesture Recognition Has Many Applications Such As Gesture Controlled Robots And Automated Homes, Game Control, Human-Computer Interaction (HCI) And Sign Language Interpretation. The Proposed System Is Used To Recognize The Real-time Signs. Hence It Is Very Much Useful For Hearing And Speech Impaired People To Communicate With Normal People.